Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Dystonia
ADR ID BADD_A01381
ADR Hierarchy
17      Nervous system disorders
17.01      Movement disorders (incl parkinsonism)
17.01.03      Dystonias
17.01.03.001      Dystonia
Description An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77) [MeSH]
MedDRA Code 10013983
MeSH ID D004421
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Dystonia | Dystonia tarda | Dystonic reaction | Involuntary dystonic movements | Dystonia aggravated | Acute dystonia | Muscle Dystonia | Dystonia, Muscle | Dystonia, Paroxysmal | Paroxysmal Dystonia | Dystonia, Diurnal | Diurnal Dystonia | Dystonia, Limb | Limb Dystonia
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
D(1A) dopamine receptorP21728T22118
Integrin alpha-MP11215T95616
Muscarinic acetylcholine receptor M2P08172T46185
Sigma non-opioid intracellular receptor 1Q99720T46360
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02441Rasagiline0.014884%
BADD_D02457Dexmethylphenidate0.000800%
BADD_D02464Fingolimod--
BADD_D02468Cannabidiol0.000338%
BADD_D02491Valbenazine0.010457%
BADD_D02507Deutetrabenazine0.002614%
BADD_D02522Lithium citrate-
BADD_D02523Hydrocortisone succinate0.005742%
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